In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription
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چکیده
منابع مشابه
HP0958 is an essential motility gene in Helicobacter pylori.
Motility is an essential colonization factor for the human gastric pathogen Helicobacter pylori. The H. pylori genome encodes most known flagellar proteins, although a number of key transcription regulators, chaperones, and structural proteins have not yet been identified. Using recently published yeast two-hybrid data we identified HP0958 as a potential motility-associated protein due to its s...
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Saha A, Hammond CE, Gooz M, Smolka AJ. IL-1 modulation of H,K-ATPase -subunit gene transcription in Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol 292: G1055–G1061, 2007. First published January 4, 2007; doi:10.1152/ajpgi.00338.2006.—Helicobacter pylori infection of the human gastric body induces hypochlorhydria by perturbing acid secretion. H. pylori inhibits parietal c...
متن کاملMolecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility.
Helicobacter pylori colonizes the human stomach and can cause gastroduodenal disease. Flagellar motility is regarded as a major factor in the colonizing ability of H. pylori. The functional roles of flagellar structural proteins other than FlaA, FlaB, and FlgE are not well understood. The fliD operon of H. pylori consists of flaG, fliD, and fliS genes, in the order stated, under the control of ...
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Previous studies have shown that Listeria monocytogenes flagellar motility genes, including flaA, encoding flagellin, are transcriptionally down-regulated at 37 degrees C. For some L. monocytogenes strains, temperature-dependent motility gene expression is less stringent. By using flaA-lacZ transcriptional fusions, we identified regions upstream of the -35/-10 promoter elements that are necessa...
متن کاملBasal Body Structures Differentially Affect Transcription of RpoN- and FliA-Dependent Flagellar Genes in Helicobacter pylori.
UNLABELLED Flagellar biogenesis in Helicobacter pylori is regulated by a transcriptional hierarchy governed by three sigma factors, RpoD (σ(80)), RpoN (σ(54)), and FliA (σ(28)), that temporally coordinates gene expression with the assembly of the flagellum. Previous studies showed that loss of flagellar protein export apparatus components inhibits transcription of flagellar genes. The FlgS/FlgR...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2010
ISSN: 1471-2180
DOI: 10.1186/1471-2180-10-210